Quinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the aminoacid Tryptophan to NAD+, a co-factor of many enzymatic reactions. It has been described to share several neurotoxic functions particularly through the activation of the N-Methyl-D-Aspartate receptor. Its production occurring in myeloid cells (macrophages, microglia, etc.) is mainly driven by inflammatory stress and is therefore suspected to play a key role in neuroinflammatory disorders such as Alzheimer and Parkinson diseases but also Multiple Sclerosis, Amyotrophic Lateral Scle- rosis. Hence, while QA has been proposed as a biomarker in these indications, it might certainly warrant further investigation to serve as a surrogate in other “inflammation” related diseases such as cancer, metabolic disorders, etc.

Key features

Citations

Product citations

Frequently asked questions

Does this product work with samples from non-human species?

Yes. This kits works in any species.

Does it work with urine?

Yes a publication was released in 2018 mentionning the use of this product in urine samples.

How do you use it for brain homogeneates?

Made a mistake ordering ? 30-day free return & refund.

Product damaged during shipping ? Free replacement.

Not getting satisfactory results ? If product did not meet quality standards, customer support offers replacement or refund.

IS-I-0100R

Quinolinic Acid ELISA kit

Quinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the aminoacid Tryptophan to NAD+, a co-factor of many enzymatic reactions.

The Quinolinic Acid ELISA kit is optimized for the quantitation of Quinolinic Acid (QUIN or QA) within serum and plasma samples. This easy-to-use competitive assay is well-suited for both small and large series of samples. Working with a low sample volume of 25µL, this assay enables pre-clinical and clinical sample testings.

Sample type	Serum, Plasma
Capacity	96 tests
Sensitivity	35.9nM
Range	150 – 12150nM
Assay time	Sample acylation 120 min, ELISA overnight
Reactivity	Reacts with all species
References	Cited in 7 papers

Free!

Pay by online or by purchase order

Pay by credit/debit card or generate a quote at checkout (your products will be sent once you provide us with the purchase order)

Fast Worldwide Shipping with Fedex

We ship your order door-to-door in all countries with FedEx International Priority^®.

Worry-free Warranty

Made a mistake ordering ? 30-day free return & refund.

Product damaged during shipping ? Free replacement.

Not getting satisfactory results ? If product did not meet quality standards, customer support offers replacement or refund.

Direct Customer Support

For questions, protocol recommendations, and troubleshooting, you have direct access to the scientist that developed the antibody or ELISA kit you’re using.

Direct customer support is available all business days.

A knowledge base containing protocols, Frequently Asked Questions, and troubleshooting tips is also available online.